She has lots to do in there

I'd suggest the odd tweak regarding ladders. The tall long one leading up is maybe a bit of a fall risk - hamsters don't balance that well. But maybe she doesn't use it and it provides some coverage under it? Would suggest having the top part a bit lower though. And the ladder up to the little front ledge is one with gaps in. Hamsters do much better with solid ramps or their legs can slip through the gaps - it might make them feel insecure trying to climb it if their legs keep slipping through and would be hard for the hamster to get down again so they'd probably just jump off the ledge.
What you could do is get a nice large cork log - it makes an interesting texture, something to climb over at low level and a big tunnel to run through - and it can also double up as a ramp. So if you place it alongside the small front ledge (at whatever angle works) that could be a route up there instead of the ladder with holes in

They just run up the side of the log.
Adding more bedding would help as well and maybe you could do that at one end - eg the end opposite the wheel. The way to keep the bedding in without it falling out of the bars, is to put cardboard or grass mats inside the bars in that area. You can attach the grass mats with sisal string (not cotton string) or, if using cardboard, I sometimes just use plastic cable ties. They are fastened on the outside of the cage with just a very small loop, pulled tight, on the inside part of the cardboard. I'm sure she'd enjoy digging and rummaging at that end and under the large and small shelves
It will make it feel a bit less exposed as well. So she might feel more confident to come out. Where is she nesting at the moment?
You could add some sprays as well, as they also make it cosier and give coverage and some hamsters enjoy nibbling at them as natural forage.
But she has a lovely large cage there and lots to do. I bet she loves her wheel.